Catalog: YP1294
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
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Main Information
Target
CDC20 Phospho Ser51
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB
MW
50kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse CDC20 (phospho-Ser51)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
50kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human CDC20 (Ser51)
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Specificity:
This antibody detects endogenous levels of Human Mouse CDC20 (phospho-Ser51)
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Gene Name:
CDC20
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Protein Name:
CDC20 (Ser51)
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Other Name:
CDC20 ;
Cell division cycle protein 20 homolog ;
p55CDC
Cell division cycle protein 20 homolog ;
p55CDC
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Database Link:
Background:
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008],
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Function:
developmental stage:Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly degraded at M/G1 transition.,Function:Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1. In metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated during mitosis, probably by maturation promoting factor (MPF).,PTM:Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint.,similarity:Belongs to the WD repeat CDC20/Fizzy family.,similarity:Contains 7 WD repeats.,subunit:Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1 (By similarity). Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C.,
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Cellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole .
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Tissue Expression:
Research Areas:
>>Cell cycle ;
>>Oocyte meiosis ;
>>Ubiquitin mediated proteolysis ;
>>Human T-cell leukemia virus 1 infection ;
>>Viral carcinogenesis
>>Oocyte meiosis ;
>>Ubiquitin mediated proteolysis ;
>>Human T-cell leukemia virus 1 infection ;
>>Viral carcinogenesis
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1294
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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