Catalog: YP1248
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
Nur77 Phospho Ser351
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
77kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA(peptide)1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous pospho levels of human Nuclear Receptor NR4A1 (Phospho-Ser351) .The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LPsKP
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
77kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized pospho peptide derived from human Nuclear Receptor NR4A1 (Phospho-Ser351)
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Specificity:
This antibody detects endogenous pospho levels of human Nuclear Receptor NR4A1 (Phospho-Ser351) .The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LPsKP
show all
Gene Name:
NR4A1 GFRP1 HMR NAK1
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Protein Name:
Nuclear Receptor NR4A1 (Phospho-Ser351)
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Other Name:
Nuclear receptor subfamily 4 group A member 1 ;
Early response protein NAK1 ;
Nuclear hormone receptor NUR/77 ;
Nur77 ;
Orphan nuclear receptor HMR ;
Orphan nuclear receptor TR3 ;
ST-59 ;
Testicular receptor 3 ;
Early response protein NAK1 ;
Nuclear hormone receptor NUR/77 ;
Nur77 ;
Orphan nuclear receptor HMR ;
Orphan nuclear receptor TR3 ;
ST-59 ;
Testicular receptor 3 ;
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Background:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],
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Function:
Function:Orphan nuclear receptor.,induction:By growth-stimulating agents.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with GADD45GIP1.,tissue specificity:Fetal muscle and adult liver, brain and thyroid.,
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Cellular Localization:
Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). .
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Tissue Expression:
Research Areas:
>>MAPK signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Cortisol synthesis and secretion ;
>>Cushing syndrome
>>PI3K-Akt signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Cortisol synthesis and secretion ;
>>Cushing syndrome
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1248
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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