Synthesized phospho-peptide around the phosphorylation site of human MER/TYRO3 (Phospho-Tyr753/Tyr685)

This antibody detects endogenous levels of MerTK/Tyro3 only when phosphorylated at Tyr753/Tyr685..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GDyYR

MERTK/TYRO3

Tyrosine-protein kinase Mer/Tyrosine-protein kinase receptor TYRO3

MERTK ;
MER ;
Tyrosine-protein kinase Mer ;
Proto-oncogene c-Mer ;
Receptor tyrosine kinase MerTK ;
TYRO3 ;
BYK ;
DTK ;
RSE ;
SKY ;
Tyrosine-protein kinase receptor TYRO3 ;
Tyrosine-protein kinase DTK ;
Tyrosine-protein kinase RSE ;
Tyrosine-protein kin

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:Defects in MERTK are a cause of retinitis pigmentosa (RP) [MIM:268000]. RP that leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,Function:In case of filovirus infection, seems to function as a cell entry factor.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.,

Cell membrane ; Single-pass type I membrane protein .