Catalog: YP1179
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
GATA-3 Phospho Ser308
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IF, ELISA
MW
48kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-GATA-3 (S308) Polyclonal Antibody detects endogenous levels of GATA-3 protein only when phosphorylated at S308.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RLsAA
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
48kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human GATA3 around the phosphorylation site of Ser308. AA range:274-323
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Specificity:
Phospho-GATA-3 (S308) Polyclonal Antibody detects endogenous levels of GATA-3 protein only when phosphorylated at S308.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RLsAA
show all
Gene Name:
GATA3
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Protein Name:
Trans-acting T-cell-specific transcription factor GATA-3
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Other Name:
GATA3 ;
Trans-acting T-cell-specific transcription factor GATA-3 ;
GATA-binding factor 3
Trans-acting T-cell-specific transcription factor GATA-3 ;
GATA-binding factor 3
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Background:
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009],
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Function:
Disease:Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.,Function:Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:T-cells and endothelial cells.,
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Cellular Localization:
Nucleus.
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Tissue Expression:
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Research Areas:
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Inflammatory bowel disease
>>Th17 cell differentiation ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Inflammatory bowel disease
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1179
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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