Catalog: YP0998
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
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0
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Main Information
Target
HAND1 Phospho Ser98
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, ELISA
MW
24kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-HAND1 (S98) Polyclonal Antibody detects endogenous levels of HAND1 protein only when phosphorylated at S98.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KGsGP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
24kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human HAND1 around the phosphorylation site of Ser98. AA range:71-120
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Specificity:
Phospho-HAND1 (S98) Polyclonal Antibody detects endogenous levels of HAND1 protein only when phosphorylated at S98.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KGsGP
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Gene Name:
HAND1
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Protein Name:
Heart- and neural crest derivatives-expressed protein 1
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Other Name:
HAND1 ;
BHLHA27 ;
EHAND ;
Heart- and neural crest derivatives-expressed protein 1 ;
Class A basic helix-loop-helix protein 27 ;
bHLHa27 ;
Extraembryonic tissues ;
heart, autonomic nervous system and neural crest derivatives-expressed protein 1 ;
eH
BHLHA27 ;
EHAND ;
Heart- and neural crest derivatives-expressed protein 1 ;
Class A basic helix-loop-helix protein 27 ;
bHLHa27 ;
Extraembryonic tissues ;
heart, autonomic nervous system and neural crest derivatives-expressed protein 1 ;
eH
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Database Link:
Background:
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008],
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Function:
Function:Plays an essential role in early trophoblast differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box).,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors).,tissue specificity:Heart.,
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Cellular Localization:
Nucleus, nucleoplasm . Nucleus, nucleolus . Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). .
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Tissue Expression:
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Research Areas:
>>Signaling pathways regulating pluripotency of stem cells
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP0998
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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