Catalog: YP0950
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
DARPP-32 Phospho Thr34
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
35kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-DARPP-32 (T34) Polyclonal Antibody detects endogenous levels of DARPP-32 protein only when phosphorylated at T34.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RPtPA
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
35kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human DARPP-32 around the phosphorylation site of Thr34. AA range:18-67
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Specificity:
Phospho-DARPP-32 (T34) Polyclonal Antibody detects endogenous levels of DARPP-32 protein only when phosphorylated at T34.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RPtPA
show all
Gene Name:
PPP1R1B
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Protein Name:
Protein phosphatase 1 regulatory subunit 1B
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Other Name:
PPP1R1B ;
DARPP32 ;
Protein phosphatase 1 regulatory subunit 1B ;
DARPP-32 ;
Dopamine- and cAMP-regulated neuronal phosphoprotein
DARPP32 ;
Protein phosphatase 1 regulatory subunit 1B ;
DARPP-32 ;
Dopamine- and cAMP-regulated neuronal phosphoprotein
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Database Link:
Background:
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
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Function:
Function:Inhibitor of protein-phosphatase 1.,PTM:Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.,PTM:Phosphorylation of Thr-34 is required for activity.,similarity:Belongs to the protein phosphatase inhibitor 1 family.,
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Cellular Localization:
Cytoplasm.
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Tissue Expression:
Research Areas:
>>cAMP signaling pathway ;
>>Dopaminergic synapse ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism
>>Dopaminergic synapse ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP0950
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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