Catalog: YP0939
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
Kv1.3 Phospho Tyr187
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
58kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-Kv1.3 (Y187) Polyclonal Antibody detects endogenous levels of Kv1.3 protein only when phosphorylated at Y187.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RFyQL
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
58kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Kv1.3/KCNA3 around the phosphorylation site of Tyr135. AA range:101-150
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Specificity:
Phospho-Kv1.3 (Y187) Polyclonal Antibody detects endogenous levels of Kv1.3 protein only when phosphorylated at Y187.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RFyQL
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Gene Name:
KCNA3
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Protein Name:
Potassium voltage-gated channel subfamily A member 3
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Other Name:
KCNA3 ;
HGK5 ;
Potassium voltage-gated channel subfamily A member 3 ;
HGK5 ;
HLK3 ;
HPCN3 ;
Voltage-gated K ;
+ ;
channel HuKIII ;
Voltage-gated potassium channel subunit Kv1.3
HGK5 ;
Potassium voltage-gated channel subfamily A member 3 ;
HGK5 ;
HLK3 ;
HPCN3 ;
Voltage-gated K ;
+ ;
channel HuKIII ;
Voltage-gated potassium channel subunit Kv1.3
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Database Link:
Background:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and
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Function:
Caution:It is uncertain whether Met-1 or Met-53 is the initiator.,Domain:The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,Domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,sequence Caution:Translation N-terminally extended.,similarity:Belongs to the potassium channel family. A (Shaker) subfamily.,subunit:Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4.,
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Cellular Localization:
Cell membrane ; Multi-pass membrane protein.
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Tissue Expression:
Reference Citation({{totalcount}})
Catalog: YP0939
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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