The antiserum was produced against synthesized peptide derived from human S6 Ribosomal Protein around the phosphorylation site of Ser235 and Ser236. AA range:200-249

This antibody detects endogenous levels of Ribosomal Protein S6 only when phosphorylated at Ser235 or Ser236,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LssLR

RPS6

40S ribosomal protein S6

RPS6 ;
OK/SW-cl.2 ;
40S ribosomal protein S6 ;
Phosphoprotein NP33

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed

Function:May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.,PTM:Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest.,similarity:Belongs to the ribosomal protein S6e family.,

nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,ribosome,polysome,small ribosomal subunit,membrane,cytosolic small ribosomal subunit,dendrite,intracellular ribonucleoprotein complex,cytoplasmic ribonucleoprotein granu

>>EGFR tyrosine kinase inhibitor resistance ;
>>Ribosome ;
>>HIF-1 signaling pathway ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Apelin signaling pathway ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Coronavirus disease - COVID-19 ;
>>Proteoglycans in cancer