Catalog: YP0738
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
ERK 3 Phospho Ser189
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
90kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-ERK 3 (S189) Polyclonal Antibody detects endogenous levels of ERK 3 protein only when phosphorylated at S189.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HLsEG
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
90kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human ERK3 around the phosphorylation site of Ser189. AA range:155-204
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Specificity:
Phospho-ERK 3 (S189) Polyclonal Antibody detects endogenous levels of ERK 3 protein only when phosphorylated at S189.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HLsEG
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Gene Name:
MAPK6
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Protein Name:
Mitogen-activated protein kinase 6
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Other Name:
MAPK6 ;
ERK3 ;
PRKM6 ;
Mitogen-activated protein kinase 6 ;
MAP kinase 6 ;
MAPK 6 ;
Extracellular signal-regulated kinase 3 ;
ERK-3 ;
MAP kinase isoform p97 ;
p97-MAPK
ERK3 ;
PRKM6 ;
Mitogen-activated protein kinase 6 ;
MAP kinase 6 ;
MAPK 6 ;
Extracellular signal-regulated kinase 3 ;
ERK-3 ;
MAP kinase isoform p97 ;
p97-MAPK
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Database Link:
Background:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation.,Function:Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.,PTM:Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.,
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Cellular Localization:
Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. .
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Tissue Expression:
Research Areas:
>>IL-17 signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP0738
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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