Catalog: YP0720
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
PKD1 Phospho Ser205
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
110kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-PKD1 (S205) Polyclonal Antibody detects endogenous levels of PKD1 protein only when phosphorylated at S205.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RLsNV
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
110kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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PKD1 (Phospho Ser205) Rabbit pAb
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PKD1 (Phospho Ser910) Rabbit pAb
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ELISA Kits
Total PKD1/PKC μ Cell-Based Colorimetric ELISA Kit
KA4243C
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PKD1/PKC μ (Phospho Tyr463) Cell-Based Colorimetric ELISA Kit
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human PKD1/PKC mu around the phosphorylation site of Ser205. AA range:171-220
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Specificity:
Phospho-PKD1 (S205) Polyclonal Antibody detects endogenous levels of PKD1 protein only when phosphorylated at S205.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RLsNV
show all
Gene Name:
PRKD1
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Protein Name:
Serine/threonine-protein kinase D1
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Other Name:
PRKD1 ;
PKD ;
PKD1 ;
PRKCM ;
Serine/threonine-protein kinase D1 ;
Protein kinase C mu type ;
Protein kinase D ;
nPKC-D1 ;
nPKC-mu
PKD ;
PKD1 ;
PRKCM ;
Serine/threonine-protein kinase D1 ;
Protein kinase C mu type ;
Protein kinase D ;
nPKC-D1 ;
nPKC-mu
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Database Link:
Background:
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by diacylglycerol and phorbol esters.,Function:Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase involved in resistance to oxidative stress.,PTM:Phosphorylation of Ser-738 and/or Ser-742 in activated PKD is mediated by transphosphorylation (By similarity). Phosphorylation of Tyr-463 mediated by the Src/Abl pathway in response to oxidative stress activates the kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Interacts (via N-terminus) with ADAP1/CENTA1. Interacts with Src.,
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Cellular Localization:
Cytoplasm . Cell membrane . Golgi apparatus, trans-Golgi network . Translocation to the cell membrane is required for kinase activation.
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Tissue Expression:
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Research Areas:
>>Rap1 signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Chemical carcinogenesis - reactive oxygen species
>>Aldosterone synthesis and secretion ;
>>Chemical carcinogenesis - reactive oxygen species
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP0720
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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