Catalog: YP0673
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
p23 Phospho Ser113
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
24kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-p23 (S113) Polyclonal Antibody detects endogenous levels of p23 protein only when phosphorylated at S113.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DDsDE
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
24kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human TEBP around the phosphorylation site of Ser113. AA range:79-128
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Specificity:
Phospho-p23 (S113) Polyclonal Antibody detects endogenous levels of p23 protein only when phosphorylated at S113.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DDsDE
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Gene Name:
PTGES3
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Protein Name:
Prostaglandin E synthase 3
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Other Name:
PTGES3 ;
P23 ;
TEBP ;
Prostaglandin E synthase 3 ;
Cytosolic prostaglandin E2 synthase ;
cPGES ;
Hsp90 co-chaperone ;
Progesterone receptor complex p23 ;
Telomerase-binding protein p23
P23 ;
TEBP ;
Prostaglandin E synthase 3 ;
Cytosolic prostaglandin E2 synthase ;
cPGES ;
Hsp90 co-chaperone ;
Progesterone receptor complex p23 ;
Telomerase-binding protein p23
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Database Link:
Background:
This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016],
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Function:
Catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.,Function:Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the p23/wos2 family.,similarity:Contains 1 CS domain.,subunit:Binds to telomerase and to the progesterone receptor.,
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Cellular Localization:
Cytoplasm .
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Tissue Expression:
Research Areas:
>>Arachidonic acid metabolism ;
>>Metabolic pathways ;
>>Chemical carcinogenesis - receptor activation
>>Metabolic pathways ;
>>Chemical carcinogenesis - receptor activation
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Reference Citation({{totalcount}})
Catalog: YP0673
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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