Catalog: YP1468
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
RIP3 Phospho Ser227
Host Species
Rabbit
Reactivity
Human
Applications
WB, IHC, ELISA
MW
56-70kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human RIP3 (phospho-Ser227)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
56-70kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human RIP3 (Ser227)
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Specificity:
This antibody detects endogenous levels of Human RIP3 (phospho-Ser227)
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Gene Name:
RIPK3 RIP3
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Protein Name:
RIP3 (Ser227)
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Other Name:
Receptor-interacting serine/threonine-protein kinase 3 ;
RIP-like protein kinase 3 ;
Receptor-interacting protein 3 ;
RIP-3 ;
RIP-like protein kinase 3 ;
Receptor-interacting protein 3 ;
RIP-3 ;
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Background:
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases , and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm , and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex , and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq , Jul 2008] ,
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Function:Promotes apoptosis. ,PTM:Autophosphorylated. ,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ,similarity:Contains 1 protein kinase domain. ,subunit:Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. ,tissue specificity:Highly expressed in the pancreas. Detected at lower levels in heart , placenta , lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. ,
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Cellular Localization:
Cytoplasm , cytosol . Nucleus . Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection. .
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Tissue Expression:
Research Areas:
>>Necroptosis ;
>>NOD-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>TNF signaling pathway ;
>>Salmonella infection
>>NOD-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>TNF signaling pathway ;
>>Salmonella infection
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1468
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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