Catalog: YP1876
Size
Price
Status
Qty.
200μL
$936.00
In stock
0
100μL
$560.00
In stock
0
50μL
$300.00
In stock
0
Add to cart
Collected
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Main Information
Target
Lamin A/C (phospho Ser392) Phospho Ser392
Host Species
Mouse
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IHC, IF, ELISA
MW
63kD,74kD (Calculated)
63kD,74kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:200-1:1000; IF 1:100-500; ELISA 1:1000-5000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
This antibody detects endogenous levels of Lamin A/C (phospho Ser392) protein.
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
63kD,74kD
MW(Observed)
63kD,74kD
Modification
phosphate
Clonality
Monoclonal
Clone Number
PTR1133
Isotype
IgG1,Kappa
Related Products
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Lamin A/C Rabbit pAb
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Lamin A/C (Phospho Ser392) Rabbit pAb
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Lamin A/C (Phospho Ser22) Rabbit pAb
YP0485
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Primary Antibodies
Cleaved Lamin A (Asn231) Rabbit pAb
YC0058
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Cleaved Lamin A (Asp230) Rabbit pAb
YC0057
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ELISA Kits
Total Lamin A/C Cell-Based Colorimetric ELISA Kit
KA4158C
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ELISA Kits
Cleaved Lamin A (Asn231) Cell-Based Colorimetric ELISA Kit
KA3930C
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ELISA Kits
Cleaved Lamin A (Asp230) Cell-Based Colorimetric ELISA Kit
KA3929C
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ELISA Kits
Lamin A/C (Phospho Ser22) Cell-Based Colorimetric ELISA Kit
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ELISA Kits
Lamin A/C (Phospho Ser392) Cell-Based Colorimetric ELISA Kit
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human protein. AA range: 350-450
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Specificity:
This antibody detects endogenous levels of Lamin A/C (phospho Ser392) protein.
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Gene Name:
LMNA LMN1
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Protein Name:
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
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Other Name:
Prelamin-A/C [Cleaved into: Lamin-A/C ;
70 kDa lamin ;
Renal carcinoma antigen NY-REN-32 ;
]
70 kDa lamin ;
Renal carcinoma antigen NY-REN-32 ;
]
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Background:
lamin A/C(LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012],
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Function:
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends . Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation . Required for osteoblastogenesis and bone formation . Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone . Required for cardiac homeostasis . ; Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
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Signaling Pathway
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Catalog: YP1876
Size
Price
Status
Qty.
200μL
$936.00
In stock
0
100μL
$560.00
In stock
0
50μL
$300.00
In stock
0
Add to cart
Collected
Collect
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