Catalog: YP0492
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
Bcl-2 Phospho Ser70
Host Species
Rabbit
Reactivity
Mouse, Rat
Applications
WB, ELISA
MW
26kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-Bcl-2 (S70) Polyclonal Antibody detects endogenous levels of Bcl-2 protein only when phosphorylated at S70.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RTsPL
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
26kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human BCL2 around the phosphorylation site of Ser70. AA range:36-85
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Specificity:
Phospho-Bcl-2 (S70) Polyclonal Antibody detects endogenous levels of Bcl-2 protein only when phosphorylated at S70.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RTsPL
show all
Gene Name:
BCL2
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Protein Name:
Apoptosis regulator Bcl-2
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Other Name:
BCL2 ;
Apoptosis regulator Bcl-2
Apoptosis regulator Bcl-2
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Background:
BCL2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Cell growth and death >> Apoptosis
Cellular Processes >> Cell growth and death >> Apoptosis - multiple species
Cellular Processes >> Cell growth and death >> Necroptosis
Cellular Processes >> Cell growth and death >> p53 signaling pathway
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Endocrine system >> Estrogen signaling pathway
Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes
Organismal Systems >> Nervous system >> Cholinergic synapse
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: overview >> MicroRNAs in cancer
Human Diseases >> Cancer: specific types >> Colorectal cancer
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Prostate cancer
Human Diseases >> Cancer: specific types >> Small cell lung cancer
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> Hedgehog signaling pathway
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway
Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
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Catalog: YP0492
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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