RPS6 (Phospho Ser240/Ser244) (PT0447R) PT™ Rabbit mAb
-YM8230
Catalog: YM8230
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
Ribosomal Protein S6 Phospho Ser240/244
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
29kD (Calculated)
32kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
IHC 1:1000-1:4000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
This antibody detects endogenous levels of Ribosomal Protein S6 only when phosphorylated at Ser240 or Ser244.
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
29kD
MW(Observed)
32kD
Modification
phosphate
Clonality
Monoclonal
Clone Number
PT0447R
Isotype
IgG, Kappa
Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
This antibody detects endogenous levels of Ribosomal Protein S6 only when phosphorylated at Ser240 or Ser244.
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Gene Name:
RPS6
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Protein Name:
40S ribosomal protein S6
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Other Name:
RPS6 ;
OK/SW-cl.2 ;
40S ribosomal protein S6 ;
Phosphoprotein NP33
OK/SW-cl.2 ;
40S ribosomal protein S6 ;
Phosphoprotein NP33
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Database Link:
Background:
Ribosomes , the organelles that catalyze protein synthesis , consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome , with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli , including growth factors , tumor-promoting agents , and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins , there are multiple processed
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Function:
Function:May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. ,PTM:Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors , tumor promoting agents , and mitogens. It is dephosphorylated at growth arrest. ,similarity:Belongs to the ribosomal protein S6e family. ,
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Cellular Localization:
nucleus ,nucleoplasm ,nucleolus ,cytoplasm ,cytosol ,ribosome ,polysome ,small ribosomal subunit ,membrane ,cytosolic small ribosomal subunit ,dendrite ,intracellular ribonucleoprotein complex ,cytoplasmic ribonucleoprotein granula
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Tissue Expression:
Research Areas:
>>EGFR tyrosine kinase inhibitor resistance ;
>>Ribosome ;
>>HIF-1 signaling pathway ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Apelin signaling pathway ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Coronavirus disease - COVID-19 ;
>>Proteoglycans in cancer
>>Ribosome ;
>>HIF-1 signaling pathway ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Apelin signaling pathway ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Coronavirus disease - COVID-19 ;
>>Proteoglycans in cancer
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Signaling Pathway
Organismal Systems >> Endocrine system >> Insulin signaling pathway
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Reference Citation({{totalcount}})
Catalog: YM8230
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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