Catalog: YP1468
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
RIP3 Phospho Ser227
Host Species
Rabbit
Reactivity
Human
Applications
WB, ELISA, IHC
MW
56-70kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human RIP3 (phospho-Ser227)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
56-70kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human RIP3 (Ser227)
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Specificity:
This antibody detects endogenous levels of Human RIP3 (phospho-Ser227)
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Gene Name:
RIPK3 RIP3
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Protein Name:
RIP3 (Ser227)
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Other Name:
Receptor-interacting serine/threonine-protein kinase 3 ;
RIP-like protein kinase 3 ;
Receptor-interacting protein 3 ;
RIP-3 ;
RIP-like protein kinase 3 ;
Receptor-interacting protein 3 ;
RIP-3 ;
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Background:
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Promotes apoptosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex.,tissue specificity:Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.,
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Cellular Localization:
Cytoplasm, cytosol . Nucleus . Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection. .
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Tissue Expression:
Research Areas:
>>Necroptosis ;
>>NOD-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>TNF signaling pathway ;
>>Salmonella infection
>>NOD-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>TNF signaling pathway ;
>>Salmonella infection
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1468
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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