The antiserum was produced against synthesized peptide derived from human Bcl-6 around the phosphorylation site of Ser333. AA range:299-348

Phospho-Bcl-6 (S333) Polyclonal Antibody detects endogenous levels of Bcl-6 protein only when phosphorylated at S333.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PQsPQ

BCL6

B-cell lymphoma 6 protein

BCL6 ;
BCL5 ;
LAZ3 ;
ZBTB27 ;
ZNF51 ;
B-cell lymphoma 6 protein ;
BCL-6 ;
B-cell lymphoma 5 protein ;
BCL-5 ;
Protein LAZ-3 ;
Zinc finger and BTB domain-containing protein 27 ;
Zinc finger protein 51

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015],

Disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.,Disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.,Disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.,Function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.,induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan.,PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.,tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.,

Nucleus .

>>FoxO signaling pathway ;
>>Transcriptional misregulation in cancer ;
>>Chemical carcinogenesis - receptor activation