Catalog: YP0123
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
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0
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Main Information
Target
GSK3α/β Phospho Tyr279/216
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IF, WB, IHC, ELISA
MW
51,46kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
IF 1:50-200; WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; Not yet tested in other applications;
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of GSK3α/β only when phosphorylated at Human:Y279/216, Mouse:Y279/216, Rat:Y279/216..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VSyIC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
51,46kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human GSK3 alpha/beta around the phosphorylation site of Tyr279/216. AA range:246-295
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Specificity:
This antibody detects endogenous levels of GSK3α/β only when phosphorylated at Human:Y279/216, Mouse:Y279/216, Rat:Y279/216..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VSyIC
show all
Gene Name:
GSK3A/GSK3B
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Protein Name:
Glycogen synthase kinase-3 alpha/beta
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Other Name:
GSK3A ;
Glycogen synthase kinase-3 alpha ;
GSK-3 alpha ;
Serine/threonine-protein kinase GSK3A ;
GSK3B ;
Glycogen synthase kinase-3 beta ;
GSK-3 beta ;
Serine/threonine-protein kinase GSK3B
Glycogen synthase kinase-3 alpha ;
GSK-3 alpha ;
Serine/threonine-protein kinase GSK3A ;
GSK3B ;
Glycogen synthase kinase-3 beta ;
GSK-3 beta ;
Serine/threonine-protein kinase GSK3B
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Database Link:
Background:
glycogen synthase kinase 3 alpha(GSK3A) Homo sapiens This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011],
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Function:
Catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,Function:Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer.,
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Cellular Localization:
apical dendrite;axon;beta-catenin destruction complex;cytoplasm;cytosol;mitochondrion;neuronal cell body;nucleus;postsynapse;proximal dendrite;
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Tissue Expression:
Research Areas:
>>Chemokine signaling pathway ;
>>Dopaminergic synapse ;
>>Non-alcoholic fatty liver disease ;
>>Shigellosis
>>Dopaminergic synapse ;
>>Non-alcoholic fatty liver disease ;
>>Shigellosis
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP0123
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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