Catalog: YV0028
Size
Price
Status
Qty.
100mg
$7,800.00
1 week
0
50mg
$5,600.00
1 week
0
25mg
$3,600.00
1 week
0
5mg
$1,100.00
1 week
0
1mg
$300.00
1 week
0
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Main Information
Target
IFN α/βRα
Host Species
Rat
Reactivity
Mouse
Applications
In vivo
Detailed Information
Formulation
0.01M PBS, pH 7.4.
Purification
Protein A/G purified from cell culture supernatant.
Purity
Endotoxin level <1 EU/mg. Purity>95% as determined by SDS-PAGE.
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Concentration
Lot depended
Clonality
Monoclonal
Isotype
IgG1, kappa
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Antigen&Target Information
Gene Name:
IFNAR1
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Protein Name:
Interferon alpha/beta receptor 1
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Other Name:
IFNAR1 ;
IFNAR ;
Interferon alpha/beta receptor 1 ;
IFN-R-1 ;
IFN-alpha/beta receptor 1 ;
Cytokine receptor class-II member 1 ;
Cytokine receptor family 2 member 1 ;
CRF2-1 ;
Type I interferon receptor 1
IFNAR ;
Interferon alpha/beta receptor 1 ;
IFN-R-1 ;
IFN-alpha/beta receptor 1 ;
Cytokine receptor class-II member 1 ;
Cytokine receptor family 2 member 1 ;
CRF2-1 ;
Type I interferon receptor 1
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Background:
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases , which in turn phosphorylate several proteins , including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq , Jul 2008] ,
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Function:
Function:Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs , TYK2 , STAT proteins and IFNR alpha- and beta-subunits themselves. ,PTM:Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. ,sequence Caution:Contaminating sequence. Potential poly-A sequence. ,similarity:Belongs to the type II cytokine receptor family. ,similarity:Contains 3 fibronectin type-III domains. ,tissue specificity:IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1 , isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R , isoform 1 is not expressed in U266R. ,
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Cellular Localization:
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Late endosome . Lysosome . Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes. .
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Research Areas:
For research use only.
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Organismal Systems >> Development and regeneration >> Osteoclast differentiation
Human Diseases >> Cancer: overview >> Pathways in cancer
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Reference Citation({{totalcount}})
Catalog: YV0028
Size
Price
Status
Qty.
100mg
$7,800.00
1 week
0
50mg
$5,600.00
1 week
0
25mg
$3,600.00
1 week
0
5mg
$1,100.00
1 week
0
1mg
$300.00
1 week
0
Add to cart
Collected
Collect
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