Catalog: YV0027
Size
Price
Status
Qty.
100mg
$7,800.00
1 week
0
50mg
$5,600.00
1 week
0
25mg
$3,600.00
1 week
0
5mg
$1,100.00
1 week
0
1mg
$300.00
1 week
0
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Main Information
Target
PDL1
Host Species
Mouse
Reactivity
Mouse
Applications
In vivo
Detailed Information
Formulation
0.01M PBS, pH 7.4.
Purification
Protein A/G purified from cell culture supernatant.
Purity
Endotoxin level <1 EU/mg. Purity>95% as determined by SDS-PAGE.
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Concentration
Lot depended
Clonality
Monoclonal
Isotype
IgG2a, kappa
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Antigen&Target Information
Gene Name:
CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1
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Protein Name:
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
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Other Name:
Programmed cell death 1 ligand 1 ;
PD-L1 ;
PDCD1 ligand 1 ;
Programmed death ligand 1 ;
B7 homolog 1 ;
B7-H1 ;
CD antigen CD274 ;
PD-L1 ;
PDCD1 ligand 1 ;
Programmed death ligand 1 ;
B7 homolog 1 ;
B7-H1 ;
CD antigen CD274 ;
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Background:
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells , such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue , this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments , this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies , including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Sep 2015] ,
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Function:
Function:Involved in the costimulatory signal , essential for T-cell proliferation and production of IL10 and IFNG , in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. ,induction:Up-regulated on T- and B-cells , dendritic cells , keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking. ,similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family. ,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain. ,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain. ,subunit:Interacts with PDCD1. ,tissue specificity:Highly expressed in the heart , skeletal muscle , placenta and lung. Weakly expressed in the thymus , spleen , kidney and liver. Expressed on activated T- and B-cells , dendritic cells , keratinocytes and monocytes. ,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Recycling endosome membrane ; Single-pass type I membrane protein . Associates with CMTM6 at recycling endosomes , where it is protected from being targeted for lysosomal degradation. .; [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Endomembrane system ; Single-pass type I membrane protein .
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Tissue Expression:
Research Areas:
For research use only.
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YV0027
Size
Price
Status
Qty.
100mg
$7,800.00
1 week
0
50mg
$5,600.00
1 week
0
25mg
$3,600.00
1 week
0
5mg
$1,100.00
1 week
0
1mg
$300.00
1 week
0
Add to cart
Collected
Collect
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