Catalog: YV0026
Size
Price
Status
Qty.
100mg
$7,800.00
1 week
0
50mg
$5,600.00
1 week
0
25mg
$3,600.00
1 week
0
5mg
$1,100.00
1 week
0
1mg
$300.00
1 week
0
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Main Information
Target
CD40
Host Species
Rat
Reactivity
Mouse
Applications
In vivo
Detailed Information
Formulation
0.01M PBS, pH 7.4.
Purification
Protein A/G purified from cell culture supernatant.
Purity
Endotoxin level <1 EU/mg. Purity>95% as determined by SDS-PAGE.
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Concentration
Lot depended
Clonality
Monoclonal
Isotype
IgG2a, kappa
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Antigen&Target Information
Gene Name:
CD40
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Protein Name:
Tumor necrosis factor receptor superfamily member 5
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Other Name:
CD40 ;
TNFRSF5 ;
Tumor necrosis factor receptor superfamily member 5 ;
B-cell surface antigen CD40 ;
Bp50 ;
CD40L receptor ;
CDw40 ;
CD antigen CD40
TNFRSF5 ;
Tumor necrosis factor receptor superfamily member 5 ;
B-cell surface antigen CD40 ;
Bp50 ;
CD40L receptor ;
CDw40 ;
CD antigen CD40
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Background:
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching , memory B cell development , and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand , which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation , and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG
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Function:
Alternative products:Additional isoforms seem to exist ,Disease:Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) [MIM:606843]. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching , one of the final differentiation steps in the humoral immune system , an inability to mount an antibody-specific immune response , and a lack of germinal center formation. ,Function:Receptor for TNFSF5/CD40LG. ,online information:CD40 entry ,online information:CD40 mutation db ,similarity:Contains 4 TNFR-Cys repeats. ,subunit:Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1 , TRAF2 , TRAF3 , TRAF5 and TRAF6. ,tissue specificity:B-cells and in primary carcinomas. ,
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Cellular Localization:
[Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.
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Tissue Expression:
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Research Areas:
For research use only.
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Signaling Pathway
Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Organismal Systems >> Immune system >> Intestinal immune network for IgA production
Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer
Human Diseases >> Immune disease >> Asthma
Human Diseases >> Immune disease >> Systemic lupus erythematosus
Human Diseases >> Immune disease >> Autoimmune thyroid disease
Human Diseases >> Immune disease >> Allograft rejection
Human Diseases >> Immune disease >> Primary immunodeficiency
Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Reference Citation({{totalcount}})
Catalog: YV0026
Size
Price
Status
Qty.
100mg
$7,800.00
1 week
0
50mg
$5,600.00
1 week
0
25mg
$3,600.00
1 week
0
5mg
$1,100.00
1 week
0
1mg
$300.00
1 week
0
Add to cart
Collected
Collect
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