Catalog: YV0025
Size
Price
Status
Qty.
100mg
$7,800.00
1 week
0
50mg
$5,600.00
1 week
0
25mg
$3,600.00
1 week
0
5mg
$1,100.00
1 week
0
1mg
$300.00
1 week
0
Add to cart
Collected
Collect
Main Information
Target
CD161
Host Species
Mouse
Reactivity
Mouse
Applications
In vivo
Detailed Information
Formulation
0.01M PBS, pH 7.4.
Purification
Protein A/G purified from cell culture supernatant.
Purity
Endotoxin level <1 EU/mg. Purity>90% as determined by SDS-PAGE.
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Concentration
Lot depended
Clonality
Monoclonal
Isotype
IgG2a, kappa
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Antigen&Target Information
Gene Name:
KLRB1
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Protein Name:
Killer cell lectin-like receptor subfamily B member 1
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Other Name:
KLRB1 ;
CLEC5B ;
NKRP1A ;
Killer cell lectin-like receptor subfamily B member 1 ;
C-type lectin domain family 5 member B ;
HNKR-P1a ;
NKR-P1A ;
Natural killer cell surface protein P1A ;
CD161
CLEC5B ;
NKRP1A ;
Killer cell lectin-like receptor subfamily B member 1 ;
C-type lectin domain family 5 member B ;
HNKR-P1a ;
NKR-P1A ;
Natural killer cell surface protein P1A ;
CD161
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Background:
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily , including the rodent NKRP1 family of glycoproteins , are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins , a transmembrane domain , and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq , Jul 2008] ,
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Function:
Function:Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha (1 ,3) Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. ,induction:By IL12 in NK cells. ,online information:NKRP1 ,PTM:N-glycosylated. Contains sialic acid residues. ,similarity:Contains 1 C-type lectin domain. ,subunit:Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1. ,tissue specificity:Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. ,
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Cellular Localization:
Membrane ; Single-pass type II membrane protein .
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Tissue Expression:
Research Areas:
For research use only.
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Reference Citation({{totalcount}})
Catalog: YV0025
Size
Price
Status
Qty.
100mg
$7,800.00
1 week
0
50mg
$5,600.00
1 week
0
25mg
$3,600.00
1 week
0
5mg
$1,100.00
1 week
0
1mg
$300.00
1 week
0
Add to cart
Collected
Collect
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