PDCD1 PD1

Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)

CD279 antibody ;
CD279 antigen antibody ;
hPD 1 antibody ;
hPD l antibody ;
hPD-1 antibody ;
hSLE1 antibody ;
PD 1 antibody ;
PD-1 antibody ;
PD1 antibody ;
PDCD 1 antibody ;
PDCD1 antibody ;
PDCD1_HUMAN antibody ;
Programmed cell death 1 antibody ;
Programmed cell death 1 protein antibody ;
Programmed cell death protein 1 antibody ;
Protein PD 1 antibody ;
Protein PD-1 antibody ;
SLEB2 antibody ;
Systemic lupus erythematosus susceptibility 2 antibody ;
CD279 nanobody ;
PD1 nanobody ;

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily.This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice , expression ofThis gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient forThis gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest thatThis gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq , Jul 2008]

developmental stage:Induced at programmed cell death. ,Disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic , inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin , joints , kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. ,Possible cell death inducer , in association with other factors. ,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain. ,subunit:Monomer. ,

Cell membrane ; Single-pass type I membrane protein.

For research use only.