Catalog: YT5456
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
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Collected
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Main Information
Target
Rab 5A
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
24kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Rab 5A Polyclonal Antibody detects endogenous levels of Rab 5A protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
24kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from the Internal region of human RAB5A. AA range:71-120
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Specificity:
Rab 5A Polyclonal Antibody detects endogenous levels of Rab 5A protein.
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Gene Name:
RAB5A
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Protein Name:
Ras-related protein Rab-5A
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Other Name:
RAB5A ;
RAB5 ;
Ras-related protein Rab-5A
RAB5 ;
Ras-related protein Rab-5A
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Background:
enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. ,function:Required for the fusion of plasma membranes and early endosomes. ,similarity:Belongs to the small GTPase superfamily. Rab family. ,subcellular location:Enriched in stage I melanosomes. ,subunit:Binds EEA1. Interacts with RIN1 and GAPVD1 , which regulate its pathway , probably by acting as a GEF. Interacts with ALS2CL , UNC84B , ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. ,
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Function:
enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. ,Function:Required for the fusion of plasma membranes and early endosomes. ,similarity:Belongs to the small GTPase superfamily. Rab family. ,subcellular location:Enriched in stage I melanosomes. ,subunit:Binds EEA1. Interacts with RIN1 and GAPVD1 , which regulate its pathway , probably by acting as a GEF. Interacts with ALS2CL , UNC84B , ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. ,
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Cellular Localization:
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Early endosome membrane ; Lipid-anchor . Melanosome . Cytoplasmic vesicle . Cell projection , ruffle . Membrane . Cytoplasm , cytosol . Cytoplasmic vesicle , phagosome membrane . Endosome membrane . Enriched in stage I melanosomes (PubMed:17081065) . Alternates between membrane-bound and cytosolic forms (Probable) . .
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Tissue Expression:
Research Areas:
>>Ras signaling pathway ;
>>Endocytosis ;
>>Phagosome ;
>>Vasopressin-regulated water reabsorption ;
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Salmonella infection ;
>>Amoebiasis ;
>>Tuberculosis
>>Endocytosis ;
>>Phagosome ;
>>Vasopressin-regulated water reabsorption ;
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Salmonella infection ;
>>Amoebiasis ;
>>Tuberculosis
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Phagosome
Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Reference Citation({{totalcount}})
Catalog: YT5456
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
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