Catalog: YP0295
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Conjugated antibody
Main Information
Target
CD19 Phospho Tyr531
Host Species
Rabbit
Reactivity
Human, Mouse, Monkey
Applications
WB, ELISA
MW
61kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-CD19 (Y531) Polyclonal Antibody detects endogenous levels of CD19 protein only when phosphorylated at Y531.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DSyEN
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
61kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human CD19 around the phosphorylation site of Tyr531. AA range:501-550
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Specificity:
Phospho-CD19 (Y531) Polyclonal Antibody detects endogenous levels of CD19 protein only when phosphorylated at Y531.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DSyEN
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Gene Name:
CD19
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Protein Name:
B-lymphocyte antigen CD19
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Other Name:
CD19 ;
B-lymphocyte antigen CD19 ;
B-lymphocyte surface antigen B4 ;
Differentiation antigen CD19 ;
T-cell surface antigen Leu-12 ;
CD antigen CD19
B-lymphocyte antigen CD19 ;
B-lymphocyte surface antigen B4 ;
Differentiation antigen CD19 ;
T-cell surface antigen Leu-12 ;
CD antigen CD19
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Background:
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008],
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Function:
Disease:Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].,Function:Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.,online information:CD19 mutation db,PTM:Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .
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Tissue Expression:
Research Areas:
>>PI3K-Akt signaling pathway ;
>>Hematopoietic cell lineage ;
>>B cell receptor signaling pathway ;
>>Epstein-Barr virus infection ;
>>Primary immunodeficiency
>>Hematopoietic cell lineage ;
>>B cell receptor signaling pathway ;
>>Epstein-Barr virus infection ;
>>Primary immunodeficiency
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP0295
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
Conjugated antibody
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