Catalog: YT0943
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
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Collected
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Main Information
Target
Claudin 1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
30kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Claudin-1 Polyclonal Antibody detects endogenous levels of Claudin-1 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
30kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Claudin 1. AA range:162-211
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Specificity:
Claudin-1 Polyclonal Antibody detects endogenous levels of Claudin-1 protein.
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Gene Name:
CLDN1
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Protein Name:
Claudin-1
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Other Name:
CLDN1 ;
CLD1 ;
SEMP1 ;
Claudin-1 ;
Senescence-associated epithelial membrane protein
CLD1 ;
SEMP1 ;
Claudin-1 ;
Senescence-associated epithelial membrane protein
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Database Link:
Background:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets , forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet , with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene , a member of the claudin family , is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq , Jul 2008] ,
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Function:
Disease:Defects in CLDN1 are the cause of ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH) [MIM:607626]; also called ichthyosis with leukocyte vacuoles alopecia and sclerosing cholangitis (ILVASC) . NISCH is a rare autosomal recessive complex ichthyosis syndrome characterized by scalp hypotrichosis , scarring alopecia , vulgar type ichthyosis , and sclerosing cholangitis. ,Function:Plays a major role in tight junction-specific obliteration of the intercellular space , through calcium-independent cell-adhesion activity (By similarity) . Acts as a co-receptor for HCV entry into hepatic cells. ,similarity:Belongs to the claudin family. ,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3 , but not CLDN2 , homopolymers. Directly interacts with TJP1/ZO-1 , TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL (By similarity) . May interact with HCV E1 and E2 proteins. ,tissue specificity:Strongly expressed in liver and kidney. Expressed in heart , brain , spleen , lung and testis. ,
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Cellular Localization:
Cell junction , tight junction . Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. .
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Tissue Expression:
Research Areas:
>>Cell adhesion molecules ;
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT0943
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
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