Catalog: YT0916
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
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Main Information
Target
Chromogranin A
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
68kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Chr-A Polyclonal Antibody detects endogenous levels of Chr-A protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
68kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Chr-A. AA range:311-360
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Specificity:
Chr-A Polyclonal Antibody detects endogenous levels of Chr-A protein.
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Gene Name:
CHGA
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Protein Name:
Chromogranin-A
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Other Name:
CHGA ;
Chromogranin-A ;
CgA ;
Pituitary secretory protein I ;
SP-I
Chromogranin-A ;
CgA ;
Pituitary secretory protein I ;
SP-I
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Background:
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin , pancreastatin , and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides , catestatin and chromofungin , have antimicrobial activity and antifungal activity , respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Sep 2014] ,
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Function:
Function:Pancreastatin strongly inhibits glucose induced insulin release from the pancreas. ,miscellaneous:Binds calcium with a low-affinity. ,PTM:Sulfated on tyrosine residues and/or contains sulfated glycans. ,similarity:Belongs to the chromogranin/secretogranin protein family. ,subcellular location:Neuroendocrine and endocrine secretory granules. ,
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Cellular Localization:
[Serpinin]: Secreted . Cytoplasmic vesicle , secretory vesicle . Pyroglutaminated serpinin localizes to secretory vesicle. .; Cytoplasmic vesicle , secretory vesicle . Cytoplasmic vesicle , secretory vesicle , neuronal dense core vesicle . Secreted . Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. In pituitary gonadotropes , located in large secretory granules. .
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Tissue Expression:
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Reference Citation({{totalcount}})
Catalog: YT0916
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
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