Glycogen synthase 1(Phospho Ser641) (PT1289R) PT™ Rabbit mAb
-YM9131
Catalog: YM9131
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
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Collected
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Main Information
Target
Glycogen Synthase 1 Phospho Phospho Ser641
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
84kD (Calculated)
84kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Glycogen synthase 1(Phospho Ser641) Antibody detects endogenous levels of Glycogen Synthase 1 protein only when phosphorylated at S641.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PAsVP
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
84kD
MW(Observed)
84kD
Modification
phosphate
Clonality
Monoclonal
Clone Number
PT1289R
Isotype
IgG,Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Glycogen synthase 1(Phospho Ser641) Antibody detects endogenous levels of Glycogen Synthase 1 protein only when phosphorylated at S641.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PAsVP
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Gene Name:
GYS1
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Protein Name:
Glycogen [starch] synthase muscle
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Other Name:
GYS1 ;
GYS ;
Glycogen [starch] synthase ;
muscle
GYS ;
Glycogen [starch] synthase ;
muscle
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Database Link:
Background:
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
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Function:
Catalytic activity:UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).,Disease:Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also called muscle glycogen synthase deficiency. GSD0 is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.,enzyme regulation:Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does.,Function:Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.,pathway:Glycan biosynthesis; glycogen biosynthesis.,similarity:Belongs to the glycosyltransferase 3 family.,
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Cellular Localization:
cytosol,membrane,inclusion body,
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Tissue Expression:
Research Areas:
>>Starch and sucrose metabolism ;
>>Metabolic pathways ;
>>PI3K-Akt signaling pathway ;
>>AMPK signaling pathway ;
>>Insulin signaling pathway ;
>>Glucagon signaling pathway ;
>>Insulin resistance ;
>>Diabetic cardiomyopathy
>>Metabolic pathways ;
>>PI3K-Akt signaling pathway ;
>>AMPK signaling pathway ;
>>Insulin signaling pathway ;
>>Glucagon signaling pathway ;
>>Insulin resistance ;
>>Diabetic cardiomyopathy
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Signaling Pathway
Organismal Systems >> Endocrine system >> Insulin signaling pathway
Organismal Systems >> Endocrine system >> Glucagon signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Reference Citation({{totalcount}})
Catalog: YM9131
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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