Catalog: YT7973
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
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Main Information
Target
LC3A
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, ELISA
MW
13kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human LC3A
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
13kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human LC3A. AA range:1-130
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Specificity:
This antibody detects endogenous levels of Human LC3A
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Gene Name:
MAP1LC3A
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Protein Name:
LC3A
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Other Name:
Microtubule-associated proteins 1A/1B light chain 3A ;
Autophagy-related protein LC3 A ;
Autophagy-related ubiquitin-like modifier LC3 A ;
MAP1 light chain 3-like protein 1 ;
MAP1A/MAP1B light chain 3 A ;
MAP1A/MAP1B LC3 A ;
Microtubule-associated protein 1 light chain 3 alpha ;
Autophagy-related protein LC3 A ;
Autophagy-related ubiquitin-like modifier LC3 A ;
MAP1 light chain 3-like protein 1 ;
MAP1A/MAP1B light chain 3 A ;
MAP1A/MAP1B LC3 A ;
Microtubule-associated protein 1 light chain 3 alpha ;
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Database Link:
Background:
function:Probably involved in formation of autophagosomal vacuoles (autophagosomes) . ,PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form , LC3-I. This is activated by APG7L/ATG7 , transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form , LC3-II. ,similarity:Belongs to the MAP1 LC3 family. ,subcellular location:LC3-II binds to the autophagic membranes. ,subunit:3 different light chains , LC1 , LC2 and LC3 , can associate with MAP1A and MAP1B proteins. ,tissue specificity:Most abundant in heart , brain , liver , skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. ,
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Function:
autophagic vacuole formation , proteolysis , autophagy , vacuole organization , macromolecule catabolic process , cellular response to starvation , response to extracellular stimulus , macroautophagy , modification-dependent protein catabolic process , protein catabolic process , response to nutrient levels , cellular response to extracellular stimulus , cellular response to nutrient levels , cellular response to stress , response to starvation , modification-dependent macromolecule catabolic process , cellular protein catabolic process , cellular macromolecule catabolic process ,proteolysis involved in cellular protein catabolic process ,
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Cellular Localization:
Cytoplasmic vesicle , autophagosome membrane ; Lipid-anchor . Endomembrane system ; Lipid-anchor . Cytoplasm , cytoskeleton . LC3-II binds to the autophagic membranes. .
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Tissue Expression:
Research Areas:
>>Mitophagy - animal ;
>>Autophagy - animal ;
>>Ferroptosis ;
>>Apelin signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis ;
>>Kaposi sarcoma-associated herpesvirus infection
>>Autophagy - animal ;
>>Ferroptosis ;
>>Apelin signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis ;
>>Kaposi sarcoma-associated herpesvirus infection
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Cellular Processes >> Cell growth and death >> Ferroptosis
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Reference Citation({{totalcount}})
Catalog: YT7973
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
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