Catalog: YT0761
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
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Collected
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Main Information
Target
CD3E
Host Species
Rabbit
Reactivity
Human, Mouse, Monkey, Rat
Applications
WB, IHC, IF, ELISA
MW
21kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
CD3-ε Polyclonal Antibody detects endogenous levels of CD3-ε protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
21kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human CD3-epsilon. AA range:22-71
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Specificity:
CD3-ε Polyclonal Antibody detects endogenous levels of CD3-ε protein.
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Gene Name:
CD3E
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Protein Name:
T-cell surface glycoprotein CD3 epsilon chain
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Other Name:
CD3E ;
T3E ;
T-cell surface glycoprotein CD3 epsilon chain ;
T-cell surface antigen T3/Leu-4 epsilon chain ;
CD antigen CD3e
T3E ;
T-cell surface glycoprotein CD3 epsilon chain ;
T-cell surface antigen T3/Leu-4 epsilon chain ;
CD antigen CD3e
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Background:
The protein encoded by this gene is the CD3-epsilon polypeptide , which together with CD3-gamma , -delta and -zeta , and the T-cell receptor alpha/beta and gamma/delta heterodimers , forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon , gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq , Jul 2008] ,
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Function:
Function:The CD3 complex mediates signal transduction. ,online information:CD3E mutation db ,similarity:Contains 1 Ig-like (immunoglobulin-like) domain. ,similarity:Contains 1 ITAM domain. ,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma , delta , epsilon , zeta , and eta. ,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein .
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Tissue Expression:
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Research Areas:
>>Hematopoietic cell lineage ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>T cell receptor signaling pathway ;
>>Chagas disease ;
>>Measles ;
>>Human T-cell leukemia virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer ;
>>Primary immunodeficiency
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>T cell receptor signaling pathway ;
>>Chagas disease ;
>>Measles ;
>>Human T-cell leukemia virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer ;
>>Primary immunodeficiency
show all
Signaling Pathway
Organismal Systems >> Immune system >> Hematopoietic cell lineage
Organismal Systems >> Immune system >> T cell receptor signaling pathway
Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation
Organismal Systems >> Immune system >> Th17 cell differentiation
Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer
Human Diseases >> Immune disease >> Primary immunodeficiency
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Catalog: YT0761
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
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