Catalog: YP0119
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
GAP-43 Phospho Ser41
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IF, ELISA
MW
25kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications;
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-GAP-43 (S41) Polyclonal Antibody detects endogenous levels of GAP-43 protein only when phosphorylated at S41.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QAsFR
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
25kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human GAP43 around the phosphorylation site of Ser41. AA range:8-57
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Specificity:
Phospho-GAP-43 (S41) Polyclonal Antibody detects endogenous levels of GAP-43 protein only when phosphorylated at S41.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QAsFR
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Gene Name:
GAP43
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Protein Name:
Neuromodulin
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Other Name:
GAP43 ;
Neuromodulin ;
Axonal membrane protein GAP-43 ;
Growth-associated protein 43 ;
Neural phosphoprotein B-50 ;
pp46
Neuromodulin ;
Axonal membrane protein GAP-43 ;
Growth-associated protein 43 ;
Neural phosphoprotein B-50 ;
pp46
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Database Link:
Background:
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
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Function:
Function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.,
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Cellular Localization:
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. .
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Tissue Expression:
Reference Citation({{totalcount}})
Catalog: YP0119
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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