The antiserum was produced against synthesized peptide derived from human GAB1 around the phosphorylation site of Tyr627 AA range:611-643

Phospho-Gab 1 (Y627) Polyclonal Antibody detects endogenous levels of Gab 1 protein only when phosphorylated at Y627.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VEyLD

GAB1

GRB2-associated-binding protein 1

GAB1 ;
GRB2-associated-binding protein 1 ;
GRB2-associated binder 1 ;
Growth factor receptor bound protein 2-associated protein 1

GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],

Function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.,

cytosol,

>>EGFR tyrosine kinase inhibitor resistance ;
>>ErbB signaling pathway ;
>>Ras signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Neurotrophin signaling pathway ;
>>Bacterial invasion of epithelial cells ;
>>Proteoglycans in cancer ;
>>Renal cell carcinoma ;
>>Hepatocellular carcinoma ;
>>Gastric cancer