Catalog: YT8067
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
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Main Information
Target
OPTN
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
65kD,42kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of OPTN at Human, Mouse,Rat
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
65kD,42kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human OPTN. AA range:163-233
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Specificity:
This antibody detects endogenous levels of OPTN at Human, Mouse,Rat
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Gene Name:
OPTN FIP2 GLC1E HIP7 HYPL NRP
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Protein Name:
OPTN
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Other Name:
Optineurin ;
E3-14.7K-interacting protein ;
FIP-2 ;
Huntingtin yeast partner L ;
Huntingtin-interacting protein 7 ;
HIP-7 ;
Huntingtin-interacting protein L ;
NEMO-related protein ;
Optic neuropathy-inducing protein ;
Transcription factor IIIA-interacting protein ;
TFIIIA-IntP ;
E3-14.7K-interacting protein ;
FIP-2 ;
Huntingtin yeast partner L ;
Huntingtin-interacting protein 7 ;
HIP-7 ;
Huntingtin-interacting protein L ;
NEMO-related protein ;
Optic neuropathy-inducing protein ;
Transcription factor IIIA-interacting protein ;
TFIIIA-IntP ;
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Database Link:
Background:
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis , inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking , vesicle trafficking , and transcription activation through its interactions with the RAB8 , huntingtin , and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq , Jul 2008]
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Cellular Localization:
Cytoplasm , perinuclear region. Golgi apparatus . Golgi apparatus , trans-Golgi network. Cytoplasmic vesicle , autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus (PubMed:27534431) . Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy. .
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Research Areas:
>>Mitophagy - animal ;
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
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Catalog: YT8067
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
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