Catalog: YT1448
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
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Main Information
Target
EAAT1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
65kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
EAAT1 Polyclonal Antibody detects endogenous levels of EAAT1 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
65kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human EAAT1. AA range:492-541
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Specificity:
EAAT1 Polyclonal Antibody detects endogenous levels of EAAT1 protein.
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Gene Name:
SLC1A3
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Protein Name:
Excitatory amino acid transporter 1
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Other Name:
SLC1A3 ;
EAAT1 ;
GLAST ;
GLAST1 ;
Excitatory amino acid transporter 1 ;
Sodium-dependent glutamate/aspartate transporter 1 ;
GLAST-1 ;
Solute carrier family 1 member 3
EAAT1 ;
GLAST ;
GLAST1 ;
Excitatory amino acid transporter 1 ;
Sodium-dependent glutamate/aspartate transporter 1 ;
GLAST-1 ;
Solute carrier family 1 member 3
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Background:
This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia , Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq , Feb 2014] ,
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Function:
Disease:Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6) [MIM:612656]. EA6 is characterized by episodic ataxia , seizures , migraine and alternating hemiplegia. ,Function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. ,PTM:Glycosylated. ,similarity:Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. ,tissue specificity:Highly expressed in cerebellum , but also found in frontal cortex , hippocampus and basal ganglia. ,
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Cellular Localization:
Cell membrane ; Multi-pass membrane protein .
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Research Areas:
>>Synaptic vesicle cycle ;
>>Glutamatergic synapse ;
>>Huntington disease
>>Glutamatergic synapse ;
>>Huntington disease
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT1448
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
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