Catalog: YN5902
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$160.00
4 weeks
0
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Collected
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Main Information
Target
FBL
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
35kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of FBL at Human, Mouse,Rat
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
35kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human FBL. AA range:1-38
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Specificity:
This antibody detects endogenous levels of FBL at Human, Mouse,Rat
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Gene Name:
FBL FIB1 FLRN
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Protein Name:
rRNA 2'-O-methyltransferase fibrillarin (34 kDa nucleolar scleroderma antigen)
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Database Link:
Background:
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3 , U8 , and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues , like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq , Jul 2008]
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Function:
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins . Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA . Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity) . Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity) . Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes . U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity . Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me) , a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus .
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Cellular Localization:
Nucleus , nucleolus . Nucleus , nucleoplasm . Fibrillar region of the nucleolus.
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Reference Citation({{totalcount}})
Catalog: YN5902
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$160.00
4 weeks
0
Add to cart
Collected
Collect
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