Catalog: YM9286
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
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Main Information
Target
NF-M Phospho Ser614/Ser619
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
103kD (Calculated)
180kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
NF-M (Phospho Ser614/Ser619) Antibody detects endogenous levels of NF-M protein only when phosphorylated at S614/S619.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KAkSP/VPkSP
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
103kD
MW(Observed)
180kD
Modification
phosphate
Clonality
Monoclonal
Clone Number
PT1444R
Isotype
IgG,Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
NF-M (Phospho Ser614/Ser619) Antibody detects endogenous levels of NF-M protein only when phosphorylated at S614/S619.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KAkSP/VPkSP
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Gene Name:
NEFM
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Protein Name:
Neurofilament medium polypeptide
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Other Name:
NEFM ;
NEF3 ;
NFM ;
Neurofilament medium polypeptide ;
NF-M ;
160 kDa neurofilament protein ;
Neurofilament 3 ;
Neurofilament triplet M protein
NEF3 ;
NFM ;
Neurofilament medium polypeptide ;
NF-M ;
160 kDa neurofilament protein ;
Neurofilament 3 ;
Neurofilament triplet M protein
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Background:
neurofilament, medium polypeptide(NEFM) Homo sapiens Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],
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Function:
Function:Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.,PTM:Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.,PTM:There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.,similarity:Belongs to the intermediate filament family.,
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Cellular Localization:
Cytoplasm, cytoskeleton . Cell projection, axon .
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Tissue Expression:
Research Areas:
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases
>>Pathways of neurodegeneration - multiple diseases
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM9286
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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