Catalog: YM960502
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
GCS-β-1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
71kD (Calculated)
68kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
71kD
MW(Observed)
68kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT2237R
Isotype
IgG, Kappa
Related Products
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
More→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
More→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
More→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
More→
Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
show all
Specificity:
Endogenous
show all
Gene Name:
GUCY1B3
show all
Protein Name:
Guanylate cyclase soluble subunit beta-1
show all
Other Name:
GUCY1B3 ;
GUC1B3 ;
GUCSB3 ;
GUCY1B1 ;
Guanylate cyclase soluble subunit beta-1 ;
GCS-beta-1 ;
Guanylate cyclase soluble subunit beta-3 ;
GCS-beta-3 ;
Soluble guanylate cyclase small subunit
GUC1B3 ;
GUCSB3 ;
GUCY1B1 ;
Guanylate cyclase soluble subunit beta-1 ;
GCS-beta-1 ;
Guanylate cyclase soluble subunit beta-3 ;
GCS-beta-3 ;
Soluble guanylate cyclase small subunit
show all
Database Link:
Background:
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC) , which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate) . The encoded protein contains an HNOX domain , which serves as a receptor for ligands such as nitric oxide , oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq , May 2014] ,
show all
Function:
Catalytic activity:GTP = 3' ,5'-cyclic GMP + diphosphate. ,cofactor:Binds 1 or 2 heme groups per heterodimer. ,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions. ,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. ,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. ,similarity:Contains 1 guanylate cyclase domain. ,subunit:Heterodimer of an alpha and a beta chain. ,
show all
Cellular Localization:
Cytoplasm .
show all
Tissue Expression:
Research Areas:
>>Purine metabolism ;
>>Metabolic pathways ;
>>cGMP-PKG signaling pathway ;
>>Vascular smooth muscle contraction ;
>>Gap junction ;
>>Platelet activation ;
>>Circadian entrainment ;
>>Long-term depression ;
>>Oxytocin signaling pathway ;
>>Renin secretion ;
>>Salivary secretion
>>Metabolic pathways ;
>>cGMP-PKG signaling pathway ;
>>Vascular smooth muscle contraction ;
>>Gap junction ;
>>Platelet activation ;
>>Circadian entrainment ;
>>Long-term depression ;
>>Oxytocin signaling pathway ;
>>Renin secretion ;
>>Salivary secretion
show all
Signaling Pathway
Cellular Processes >> Cellular community - eukaryotes >> Gap junction
Organismal Systems >> Immune system >> Platelet activation
Organismal Systems >> Endocrine system >> Oxytocin signaling pathway
Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction
Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Reference Citation({{totalcount}})
Catalog: YM960502
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}