Catalog: YM6267
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
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Main Information
Target
Glutamine Synthetase
Host Species
Rabbit
Reactivity
Human
Applications
IHC
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:400
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT167
Isotype
IgG, Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Endogenous
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Gene Name:
GLUL
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Protein Name:
Glutamine synthetase
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Other Name:
GLUL ;
GLNS ;
Glutamine synthetase ;
GS ;
Glutamate decarboxylase ;
Glutamate--ammonia ligase
GLNS ;
Glutamine synthetase ;
GS ;
Glutamate decarboxylase ;
Glutamate--ammonia ligase
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Database Link:
Background:
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification , acid-base homeostasis , cell signaling , and cell proliferation. Glutamine is an abundant amino acid , and is important to the biosynthesis of several amino acids , pyrimidines , and purines. Mutations in this gene are associated with congenital glutamine deficiency , and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2 , 5 , 9 , 11 , and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Dec 2014] ,
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Function:
Catalytic activity:ATP + L-glutamate + NH (3) = ADP + phosphate + L-glutamine. ,Disease:Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum , urine and cerebrospinal fluid. ,online information:Glutamine synthetase entry ,similarity:Belongs to the glutamine synthetase family. ,subunit:Homooctamer. ,
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Cellular Localization:
Cytoplasm , Membrane
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Tissue Expression:
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM6267
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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