• Target：
• IL-3Rβ

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Apoptosis;>>JAK-STAT signaling pathway;>>Pathways in cancer

• Gene Name：
• CSF2RB

• Protein Name：
• Cytokine receptor common subunit beta

• Human Gene Id：
• 1439

• Human Swiss Prot No：
• P32927

• Mouse Gene Id：
• 12983

• Mouse Swiss Prot No：
• P26955

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human IL-3R beta around the phosphorylation site of Tyr593. AA range:559-608

• Specificity：
• Phospho-IL-3Rβ (Y593) Polyclonal Antibody detects endogenous levels of IL-3Rβ protein only when phosphorylated at Y593.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CSF2RB;IL3RB;IL5RB;Cytokine receptor common subunit beta;CDw131;GM-CSF/IL-3/IL-5 receptor common beta subunit;CD antigen CD131

• Observed Band(KD)：
• 125kD

• Background：
• The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.,

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Placenta,

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