Arginase-1(ABT-Arg1) mouse mAb

    • Catalog No.:YM6684
    • Applications:IHC-p,WB
    • Reactivity:Human
      • Gene Name:
      • ARG1
      • Protein Name:
      • Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
      • Human Gene Id:
      • 383
      • Human Swiss Prot No:
      • P05089
      • Immunogen:
      • Synthesized peptide derived from human Arginase-1
      • Specificity:
      • This antibody detects endogenous levels of human Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse/IgG2b, Kappa
      • Dilution:
      • IHC-p 1:100-500,WB 1:500-2000
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Background:
      • arginase 1(ARG1) Homo sapiens Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
      • Function:
      • catalytic activity:L-arginine + H(2)O = L-ornithine + urea.,cofactor:Binds 2 manganese ions per subunit.,disease:Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.,induction:By arginine or homoarginine.,online information:Arginase entry,pathway:Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.,similarity:Belongs to the arginase family.,subunit:Homotrimer.,
      • Subcellular Location:
      • Cytoplasmic, Nuclear
      • Expression:
      • Blood,Erythroblast,Liver,Skeletal muscle,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded human Hepatocellular carcinoma. 1,Arginase-1 Antibody was diluted at 1:200(4°,overnight). 2, EDTA pH 8.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Hepatocellular carcinoma. 1,Arginase-1 Antibody was diluted at 1:200(4°,overnight). 2, EDTA pH 8.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Hepatocellular carcinoma. 1,Arginase-1 Antibody was diluted at 1:200(4°,overnight). 2, EDTA pH 8.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Hepatocellular carcinoma. 1,Arginase-1 Antibody was diluted at 1:200(4°,overnight). 2, EDTA pH 8.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Hepatocellular carcinoma. 1,Arginase-1 Antibody was diluted at 1:200(4°,overnight). 2, EDTA pH 8.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Hepatocellular carcinoma. 1,Arginase-1 Antibody was diluted at 1:200(4°,overnight). 2, EDTA pH 8.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Hepatocellular carcinoma. 1,Arginase-1 Antibody was diluted at 1:200(4°,overnight). 2, EDTA pH 8.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Hepatocellular carcinoma. 1,Arginase-1 Antibody was diluted at 1:200(4°,overnight). 2, EDTA pH 8.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Hepatocellular carcinoma. 1,Arginase-1 Antibody was diluted at 1:200(4°,overnight). 2, EDTA pH 8.0 was used for antigen retrieval