• Target：
• SmcX

• Gene Name：
• KDM5C

• Protein Name：
• Lysine-specific demethylase 5C

• Human Gene Id：
• 8242

• Human Swiss Prot No：
• P41229

• Mouse Gene Id：
• 20591

• Mouse Swiss Prot No：
• P41230

• Immunogen：
• Purified recombinant human SmcX (C-terminus) protein fragments expressed in E.coli.

• Specificity：
• SmcX Monoclonal Antibody detects endogenous levels of SmcX protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.

• Purification：
• Affinity purification

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• KDM5C;DXS1272E;JARID1C;SMCX;XE169;Lysine-specific demethylase 5C;Histone demethylase JARID1C;Jumonji/ARID domain-containing protein 1C;Protein SmcX;Protein Xe169

• Molecular Weight(Da)：
• 176kD

• Background：
• This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],

• Function：
• cofactor:Alpha-ketoglutarate.,cofactor:Fe(2+).,disease:Defects in KDM5C are a cause of X-linked mental retardation (XLMR) [MIM:300534]. Mental retardation is usually defined as cognitive impairment with an IQ less than 70. Etiologically, mental retardation is a very heterogeneous condition that involves environmental, stochastic and/or genetic factors.,domain:Both the JmjC domain and the JmjN domain are required for enzymatic activity.,domain:The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.,function:Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting hist

• Subcellular Location：
• Nucleus .

• Expression：
• Expressed in all tissues examined. Highest levels found in brain and skeletal muscle.

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