• Target：
• CD73

• Fields：
• >>Purine metabolism;>>Pyrimidine metabolism;>>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Nucleotide metabolism

• Gene Name：
• NT5E

• Protein Name：
• 5'-nucleotidase

• Human Gene Id：
• 4907

• Human Swiss Prot No：
• P21589

• Mouse Swiss Prot No：
• Q61503

• Immunogen：
• Purified recombinant fragment of CD73 expressed in E. Coli.

• Specificity：
• CD73 Monoclonal Antibody detects endogenous levels of CD73 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• NT5E;NT5;NTE;5'-nucleotidase;5'-NT;Ecto-5'-nucleotidase;CD antigen CD73

• References：
• 1. Oncol Rep. 2007 Jun;17(6):1341-6.
  2. Neurochem Int. 2003 Dec;43(7):621-8.

• Background：
• The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011],

• Function：
• catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Zinc.,disease:There is a decrease in the activity of NT5 in B-cell chronic lymphocytic leukemia.,function:Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.,similarity:Belongs to the 5'-nucleotidase family.,subunit:Homodimer; disulfide-linked.,

• Subcellular Location：
• Cell membrane ; Lipid-anchor, GPI-anchor .

• Expression：
• Leukocyte,Liver,Placenta,Skin,

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