CD38 Monoclonal Antibody

    • Catalog No.：YM0122
    • Applications：WB;IHC;IF;ELISA
    • Reactivity：Human
      • Target：
      • CD38
      • Fields：
      • >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Hematopoietic cell lineage;>>Oxytocin signaling pathway;>>Salivary secretion;>>Pancreatic secretion
      • Gene Name：
      • CD38
      • Protein Name：
      • ADP-ribosyl cyclase 1
      • Human Gene Id：
      • 952
      • Human Swiss Prot No：
      • P28907
      • Mouse Swiss Prot No：
      • P56528
      • Immunogen：
      • Purified recombinant fragment of human CD38 expressed in E. Coli.
      • Specificity：
      • CD38 Monoclonal Antibody detects endogenous levels of CD38 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • CD38;ADP-ribosyl cyclase 1;Cyclic ADP-ribose hydrolase 1;cADPr hydrolase 1;T10;CD antigen CD38
      • Molecular Weight(Da)：
      • 34kD
      • References：
      • 1. Trends Biochem Sci. 1992 Dec;17(12):495.
        2. J Cell Biol. 1999 Sep 6;146(5):1161-72.
        3. Exp Hematol. 2002 Jun;30(6):582-9.
        4. Mol Immunol. 2006 Mar;43(7):1029-39.
      • Background：
      • The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
      • Function：
      • catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.,enzyme regulation:ATP inhibits the hydrolyzing activity.,function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.,online information:CD38 entry,similarity:Belongs to the ADP-ribosyl cyclase family.,tissue specificity:Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.,
      • Subcellular Location：
      • Membrane; Single-pass type II membrane protein.
      • Expression：
      • Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
      • Products Images
      • Western Blot analysis using CD38 Monoclonal Antibody against CD38-hIgGFc transfected HEK293 cell lysate.
      • Immunohistochemistry analysis of paraffin-embedded human lung cancer (A), lymphonodus tissue (B), showing cytomembrane localization with DAB staining using CD38 Monoclonal Antibody.

      Attributes

      • Code：
      • YM0122
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-05-11
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