RIP140 (Acetyl Lys158) Polyclonal Antibody

    • Catalog No.:YK0069
    • Applications:WB,ELISA
    • Reactivity:Human,Mouse,Rat
      • Gene Name:
      • NRIP1
      • Protein Name:
      • Nuclear receptor-interacting protein 1
      • Human Gene Id:
      • 8204
      • Human Swiss Prot No:
      • P48552
      • Mouse Swiss Prot No:
      • Q8CBD1
      • Immunogen:
      • Synthesized acetyl-peptide derived from human RIP140 around the acetylation site of K158.
      • Specificity:
      • Acetyl-RIP140 (K158) Polyclonal Antibody detects endogenous levels of RIP140 around the acetylation site of K158 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • NRIP1; Nuclear receptor-interacting protein 1; Nuclear factor RIP140; Receptor-interacting protein 140
      • Background:
      • nuclear receptor interacting protein 1(NRIP1) Homo sapiens Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008],
      • Function:
      • disease:Genetic variation in NRIP1 may act as predisposing factor for endometriosis.,domain:Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type. RD2 is dependent on CTBP binding.,function:Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors.,PTM:Acetylation regulates its nucle
      • Subcellular Location:
      • histone deacetylase complex,nuclear chromatin,nucleus,nucleoplasm,nucleolus,nuclear speck,cell junction,
      • Expression:
      • Brain,Epithelium,Mammary gland,Skin,
      • Products Images
      • Western blot analysis of 293T using Acetyl-RIP140 (K158) antibody. Antibody was diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000