Actin, sarcomeric muscle(PT2240) mouse mAb

    • 货号:YM6604
    • 应用:IHC-p,IF(paraffin section)
    • 种属:Human
      • 基因名称:
      • ACTA1 ACTA ACTC1 ACTC
      • 免疫原:
      • Synthesized peptide derived from human Actin, sarcomeric muscle
      • 特异性:
      • This antibody detects endogenous levels of human . Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Mouse/IgG1, Kappa
      • 稀释:
      • IHC-p 1:100-500
      • 纯化工艺:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • 储存:
      • -20°C/1 year
      • 背景:
      • actin, alpha 1, skeletal muscle(ACTA1) Homo sapiens The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008],
      • 功能:
      • disease:Defects in ACTA1 are a cause of congenital myopathy with excess of thin myofilaments (CM) [MIM:102610].,disease:Defects in ACTA1 are a cause of congenital myopathy with fiber-type disproportion (CFTD) [MIM:255310]; also known as congenital fiber-type disproportion myopathy (CFTDM). CFTD is a genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.,disease:Defects in ACTA1 are the cause of nemaline myopathy type 3 (NEM3) [MIM:161800]. Nemaline myopathy (NEM) is a form of congenital myopathy characterized by abnormal thread- or rod-like structures in muscle fibers on histologic examination. The clinical phenotype is highly variable, with differing age at onset and severity.,func
      • 细胞定位:
      • Cytoplasmic
      • 组织表达:
      • Epithelium,Skeletal muscle,
      • 产品图片
      • Immunohistochemical analysis of paraffin-embedded human Myocardium. 1,Actin, sarcomeric muscle Antibody was diluted at 1:200(4° overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Myocardium. 1,Actin, sarcomeric muscle Antibody was diluted at 1:200(4° overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Prostate. 1,Actin, sarcomeric muscle Antibody was diluted at 1:200(4° overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Skeletal muscle. 1,Actin, sarcomeric muscle Antibody was diluted at 1:200(4° overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Smooth muscle. 1,Actin, sarcomeric muscle Antibody was diluted at 1:200(4° overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval