Acetyl P53(K382) mouse Monoclonal Antibody(1G7)

  • 货号:YM3760
  • 应用:IHC-p,IF(paraffin section)
  • 种属:Human,Mouse,Rat
    • 基因名称:
    • TP53 P53
    • 蛋白名称:
    • Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
    • Human Gene Id:
    • 7157
    • Human Swiss Prot No:
    • P04637
    • Mouse Swiss Prot No:
    • P02340
    • 免疫原:
    • Synthetic Peptide of human Acetyl P53(K382)
    • 特异性:
    • The antibody detects endogenous Acetyl P53(K382) protein in human, Acetyl P53(K379) protein in mouse, Acetyl P53(K380) protein in Rat
    • 组成:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源:
    • Mouse
    • 稀释:
    • IF(paraffin section) 1:50-200 IHC-p 1:50-300
    • 纯化工艺:
    • The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -20°C/1 year
    • 其他名称:
    • Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
    • 实测条带:
    • 53
    • 背景:
    • tumor protein p53(TP53) Homo sapiens This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013],
    • 功能:
    • cofactor:Binds 1 zinc ion per subunit.,disease:Defects in TP53 are a cause of choroid plexus papilloma [MIM:260500]. Choroid plexus papilloma is a slow-growing benign tumor of the choroid plexus that often invades the leptomeninges. In children it is usually in a lateral ventricle but in adults it is more often in the fourth ventricle. Hydrocephalus is common, either from obstruction or from tumor secretion of cerebrospinal fluid. If it undergoes malignant transformation it is called a choroid plexus carcinoma. Primary choroid plexus tumors are rare and usually occur in early childhood.,disease:Defects in TP53 are a cause of Li-Fraumeni syndrome (LFS) [MIM:151623]. LFS is an autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years a
    • 细胞定位:
    • nuclear chromatin,nucleus,nucleoplasm,replication fork,transcription factor TFIID complex,nucleolus,cytoplasm,mitochondrion,mitochondrial matrix,endoplasmic reticulum,cytosol,integral component of membrane,nuclear matrix,
    • 组织表达:
    • Blood,Brain,Classical Hodgkin Lymphoma,Esophageal squamous cell carcinoma,Glial cell,Glial