PLX7904(PB04)

    • 货号:MC1223
      • CasNo:
      • 1393465-84-3
      • 分子式:
      • C24H22F2N6O3S
      • 纯度:
      • >98%
      • 靶点:
      • Raf
      • IC50:
      • IC50: appr 5 nM (BRAFV600E, in mutant RAS expressing cells)[2]
      • 体外研究:
      • PLX7904 inhibits the in vitro growth of two melanoma cell lines (A375 and COLO829) and an additional human colorectal cancer cell line COLO205 that expresses BRAFV600E with IC50 values of 0.17 μM, 0.53 μM, and 0.16 μM, respectively, on a par with vemurafenib IC50 values in the same assays (0.33 μM, 0.69 μM, and 0.25 μM, respectively)[1]. PLX7904 and PLX8394 potently inhibit ERK1/2-driven GAL4-Elk1 reporter activity in PRT cells as well as parental cells. PLX7904 and PLX8394 treatment at 1 μM concentration reduce colony formation and viability in parental cells to a similar level as PLX4720[2]. PPLX7904 potently inhibits phosphorylation of ERK1/2 in mutant BRAF melanoma cells without eliciting paradoxical activation in wild-type BRAF, mutant NRAS melanoma cells. PPLX7904 inhibits ERK1/2 in PLX470-resistant cell lines. PPLX7904 treatment promotes apoptosis and inhibits anchorage-independent growth of vemurafenib resistant cells[3].
      • 体内研究:
      • 简介:
      • PLX7904(PB04) is a potent and selective paradox-breaker RAF inhibitor. IC50: appr 5 nM (BRAFV600E, in mutant RAS expressing cells)[2]
      • 特异性:
      • Target: Raf. Fields: PLX7904(PB04) is a potent and selective paradox-breaker RAF inhibitor. IC50: appr 5 nM (BRAFV600E, in mutant RAS expressing cells)[2]
      • 稀释:
      • IC50: appr 5 nM (BRAFV600E, in mutant RAS expressing cells)[2]
      • 浓度:
      • >98%
      • 储存:
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • 其他名称:
      • PLX-7904,PLX 7907,PB04; PB-04; PB 04; paradox-breaker-04
      • 分子量:
      • 512.14
      • 产品图片