• Target：
• MRP2

• Fields：
• >>Antifolate resistance;>>Platinum drug resistance;>>ABC transporters;>>Bile secretion

• Gene Name：
• ABCC2

• Protein Name：
• Canalicular multispecific organic anion transporter 1

• Human Gene Id：
• 1244

• Human Swiss Prot No：
• Q92887

• Mouse Swiss Prot No：
• Q8VI47

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ABCC2. AA range:991-1040

• Specificity：
• MRP2 Polyclonal Antibody detects endogenous levels of MRP2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ABCC2;CMOAT;CMOAT1;CMRP;MRP2;Canalicular multispecific organic anion transporter 1;ATP-binding cassette sub-family C member 2;Canalicular multidrug resistance protein;Multidrug resistance-associated protein 2

• Molecular Weight(Da)：
• 175kD

• Observed Band(KD)：
• 190-250kD

• Background：
• The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.,function:Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.,

• Subcellular Location：
• Apical cell membrane ; Multi-pass membrane protein .

• Expression：
• Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

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