• Target：
• 53BP1

• Fields：
• >>NOD-like receptor signaling pathway

• Gene Name：
• TP53BP1

• Protein Name：
• 53BP1 (Ser1778)

• Human Gene Id：
• 7158

• Human Swiss Prot No：
• Q12888

• Mouse Gene Id：
• 27223

• Mouse Swiss Prot No：
• P70399

• Immunogen：
• Synthesized phosho peptide around human 53BP1 (Ser1778)

• Specificity：
• This antibody detects endogenous levels of Human 53BP1 (phospho-Ser1778)

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:1000-2000

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)

• Observed Band(KD)：
• 213kD

• Function：
• function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to th

• Subcellular Location：
• Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity). .

• Expression：
• Cerebellum,Cervix,Epithelium,Myeloid leukemia cell,Skeletal muscle,

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