Histone H3 (citrulline R2 + R8 + R17) rabbit pAb

  • 货号:YP1800
  • 应用:WB
  • 种属:Human;Mouse;Rat
    • 靶点:
    • Histone H3
    • 简介:
    • >>Neutrophil extracellular trap formation;>>Alcoholism;>>Shigellosis;>>Transcriptional misregulation in cancer;>>Systemic lupus erythematosus
    • 基因名称:
    • HIST1H3A H3FA; HIST1H3B H3FL; HIST1H3C H3FC; HIST1H3D H3FB; HIST1H3E H3FD; HIST1H3F H3FI; HIST1H3G H3FH; HIST1H3H H3FK; HIST1H3I H3FF; HIST1H3J H3FJ
    • 蛋白名称:
    • Histone H3 (citrulline R2 + R8 + R17)
    • Human Gene Id:
    • 8350
    • Human Swiss Prot No:
    • P68431
    • Mouse Swiss Prot No:
    • P68433
    • 免疫原:
    • Synthesized peptide derived from human Histone H3 (citrulline R2 + R8 + R17)
    • 特异性:
    • This antibody detects endogenous levels of Histone H3 (citrulline R2 + R8 + R17) at Human, Mouse,Rat
    • 组成:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源:
    • Polyclonal, Rabbit,IgG
    • 稀释:
    • WB 1:500-2000
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称:
    • Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
    • 分子量:
    • 15kD
    • 背景:
    • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015],
    • 功能:
    • caution:Was originally (PubMed:2587222) thought to originate from mouse.,developmental stage:Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.,function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,miscellaneous:This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).,PTM:Acetylation is generally l
    • 细胞定位:
    • Nucleus. Chromosome.
    • 组织表达:
    • Blood,Epithelium,Kidney,Lung,Ovary,Spleen,Uterus,