Synuclein-α Polyclonal Antibody

    • Catalog No.：YT5731
    • Applications：WB;IHC;IF;ELISA
    • Reactivity：Human;Mouse;Rat
      • Target：
      • Synuclein-α
      • Fields：
      • >>Alzheimer disease;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases
      • Gene Name：
      • SNCA
      • Protein Name：
      • Alpha-synuclein
      • Human Gene Id：
      • 6622
      • Human Swiss Prot No：
      • P37840
      • Mouse Swiss Prot No：
      • O55042
      • Immunogen：
      • The antiserum was produced against synthesized peptide derived from the Internal region of human SNCA. AA range:21-70
      • Specificity：
      • Synuclein-α Polyclonal Antibody detects endogenous levels of Synuclein-α protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500-2000;IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • SNCA;NACP;PARK1;Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP
      • Observed Band(KD)：
      • 15kD
      • Background：
      • Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016],
      • Function：
      • alternative products:Additional isoforms seem to exist,disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCA is found in LB-like inclusions, glial inclusions and spheroids.,disease:Defects in SNCA are a cause of autosomal dominant Parkinson disease 1 (PARK1) [MIM:168601, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages an
      • Subcellular Location：
      • Cytoplasm . Membrane . Nucleus . Cell junction, synapse . Secreted . Cell projection, axon . Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). .
      • Expression：
      • Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain.
      • Products Images
      • Western blot analysis of hela lysis using SNCA antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Immunohistochemical analysis of paraffin-embedded mouse-brain, antibody was diluted at 1:200

      Attributes

      • Code：
      • YT5731
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-04-26
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