• Target：
• SEC22B

• Fields：
• >>SNARE interactions in vesicular transport;>>Phagosome;>>Legionellosis

• Gene Name：
• SEC22B

• Protein Name：
• Vesicle-trafficking protein SEC22b

• Human Gene Id：
• 9554

• Human Swiss Prot No：
• O75396

• Mouse Gene Id：
• 20333

• Mouse Swiss Prot No：
• O08547

• Rat Gene Id：
• 310710

• Rat Swiss Prot No：
• Q4KM74

• Immunogen：
• Synthesized peptide derived from the Internal region of human SEC22B.

• Specificity：
• SEC22B Polyclonal Antibody detects endogenous levels of SEC22B protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SEC22B;SEC22L1;Vesicle-trafficking protein SEC22b;ER-Golgi SNARE of 24 kDa;ERS-24;ERS24;SEC22 vesicle-trafficking protein homolog B;SEC22 vesicle-trafficking protein-like 1

• Observed Band(KD)：
• 23kD

• Background：
• The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009],

• Function：
• function:SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 longin domain.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex.,

• Subcellular Location：
• Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane . Golgi apparatus, cis-Golgi network membrane . Golgi apparatus, trans-Golgi network membrane . Melanosome . Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

• Expression：
• Caudate nucleus,Platelet,Skin,Umbilical cor

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