• Target：
• ApoC-III

• Fields：
• >>PPAR signaling pathway;>>Cholesterol metabolism

• Gene Name：
• APOC3

• Protein Name：
• Apolipoprotein C-III

• Human Gene Id：
• 345

• Human Swiss Prot No：
• P02656

• Mouse Swiss Prot No：
• P33622

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the C-terminal region of human APOC3. AA range:46-95

• Specificity：
• ApoC-III Polyclonal Antibody detects endogenous levels of ApoC-III protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• APOC3;Apolipoprotein C-III;Apo-CIII;ApoC-III;Apolipoprotein C3

• Observed Band(KD)：
• 11kD

• Background：
• Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in APOC3 may be a cause of hyperalphalipoproteinemia [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).,function:Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.,PTM:O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues.,similarity:Belongs to the apolipoprotein C3 family.,tissue specificity:Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.,

• Subcellular Location：
• Secreted .

• Expression：
• Liver.

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