• Target：
• GGH

• Fields：
• >>Folate biosynthesis;>>Biosynthesis of cofactors;>>Antifolate resistance

• Gene Name：
• GGH

• Protein Name：
• Gamma-glutamyl hydrolase

• Human Gene Id：
• 8836

• Human Swiss Prot No：
• Q92820

• Mouse Swiss Prot No：
• Q9Z0L8

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GGH. AA range:251-300

• Specificity：
• GGH Polyclonal Antibody detects endogenous levels of GGH protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GGH;Gamma-glutamyl hydrolase;Conjugase;GH;Gamma-Glu-X carboxypeptidase

• Observed Band(KD)：
• 36kD

• Background：
• This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:Hydrolysis of a gamma-glutamyl bond.,function:Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.,similarity:Belongs to the peptidase C26 family.,similarity:Contains 1 gamma-glutamyl hydrolase domain.,subcellular location:While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,

• Subcellular Location：
• Secreted, extracellular space . Lysosome . Melanosome . While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .

• Expression：
• Skin,

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